Published Studies


Avgidou K, Papageorghiou A, Bindra R, Spencer K, Nicolaides KH. (2005) Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies. American Journal of Obstetrics and Gynecology 192: 1761-7.

Orlandi F, Rossi C, Orlandi E, Jakil MC, Hallahan TW, Macri VJ, Krantz DA. (2005) First-trimester screening for trisomy-21 using a simplified method to assess the presence or absence of the fetal nasal bone. American Journal of Obstetrics and Gynecology 192: 1107-11.

Nicolaides KH. (2004) Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities. American Journal of Obstetrics and Gynecology 191: 45-67.

ACOG Committee Opinion #296: first-trimester screening for fetal aneuploidy. (2004) Obstetrics & Gynecology 104(1): 215-7.

Borrell A, Casals E, Fortuny A, Farre MT, Gonce A, Sanchez A, Soler A, Cararach V, Vanrell JA (2004) First-trimester screening for trisomy 21 combining biochemistry and ultrasound at individually optimal gestational ages. An interventional study. Prenatal Diagnosis 24(7): 541-5.

Cicero S, Longo D, Rembouskos G, Sacchini C, Nicolaides KH. (2003) Absent nasal bone at 11-14 weeks of gestation and chromosomal defects. Ultrasound in Obstetrics and Gynecology 22(1): 31-5.

Spencer K, Spencer CE, Power M, Dawson C, Nicolaides KH. (2003) Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years prospective experience. BJOG: An International Journal of Obstetrics and Gynaecology 110(3): 281-6.

Wapner R, Thom E, Simpson JL, Pergament E, Silver R, Filkins K, Platt L, Mahoney M, Johnson A, Hogge WA, Wilson RD, Mohide P, Hershey D, Krantz D, Zachary J, Snijders R, Greene N, Sabbagha R, MacGregor S, Hill L, Gagnon A, Hallahan T, Jackson L; First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group. (2003) First-trimester screening for trisomies 21 and 18. New England Journal of Medicine 349(15): 1405-13.

Bindra R, Heath V, Liao A, Spencer K, Nicolaides KH. (2002) One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15 030 pregnancies. Ultrasound in Obstetrics and Gynecology 20(3): 219-25.

Schuchter K, Hafner E, Stangl G, Metzenbauer M, Hofinger D, Philipp K. (2002) The first trimester 'combined test' for the detection of Down syndrome pregnancies in 4939 unselected pregnancies. Prenatal Diagnosis 22(3): 211-5.

Niemimaa M, Suonpaa M, Perheentupa A, Seppala M, Heinonen S, Laitinen P, Ruokonen A, Ryynanen M. (2001) Evaluation of first trimester maternal serum and ultrasound screening for Down's syndrome in Eastern and Northern Finland. European Journal of Human Genetics 9(6): 404-8.

Krantz DA, Hallahan TW, Orlandi F, Buchanan P, Larsen JW Jr, Macri JN. (2000) First-trimester Down syndrome screening using dried blood biochemistry and nuchal translucency. Obstetrics & Gynecology 96(2): 207-13.

Spencer K, Souter V, Tul N, Snijders R, Nicolaides KH. (1999) A screening program for trisomy 21 at 10-14 weeks using fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A. Ultrasound in Obstetrics & Gynecology 13(4): 231-7.